by Elizabeth Swanberg | Apr 22, 2019 | Introductory Workflows, Workflows
Delta Delta G (DDG) is a metric for predicting how a single point mutation will affect protein stability. To read more background information on DDG click here. 1.) Begin in CAD by clicking the folder on the left that contains your protein structure to bring it into...
by Elizabeth Swanberg | Apr 22, 2019 | FAQs
Please email support@cyrusbio.com to request to add another...
by Elizabeth Swanberg | Jan 20, 2019 | FAQs
If you see this error: ‘Please ensure that your collection name contains only valid characters as defined at support.cyrusbio.com‘ You have entered a non-accepted symbol into a name field. Below are the only symbols that are allowed in name fields:...
by Elizabeth Swanberg | Jan 20, 2019 | FAQs
You can reset your password by visiting accounts.cyrusbio.com and clicking Trigger Password Reset....
by Elizabeth Swanberg | Jan 20, 2019 | Advanced use of Design, Workflows
After running DDG, users often want to select mutations that are found to be favorable as a mutation set for Design. We are working on adding an automatic implementation for this in CAD, but in the meantime you can download a program that will do it for you. This tool...
by Elizabeth Swanberg | Jan 20, 2019 | Advanced use of Design, Workflows
Workflows for rescoring protein-protein complex from other software, and disulfide bond removal with maintained overall...
by Elizabeth Swanberg | Jan 20, 2019 | Antibodies, Workflows
BACKGROUND B Cells can have surface antibodies that can bind proteins. This can elicit an immune response if other factors are present to activate the B Cell. One way to inhibit or increase antibody binding to a protein is to alter its surface residues to change the...
by Elizabeth Swanberg | Jan 20, 2019 | Introductory Workflows, Workflows
INTERFACE DDG WORKFLOW The free energy of an interface single point mutation (change in binding free energy) can be calculated using this workflow. Here we will look at mutations on the alpha-helical peptide BHRF1 in complex with the Bim BH3 domain, 2WH6. STEP BY...
