Generic selectors
Exact matches only
Search in title
Search in content
Search in posts
Search in pages
Select Page

Antibody HM

The antibody homology modeling API creates homology models of antibodies using the Cyrus NextGen Antibody structure prediction method.   This method takes as input an antibody heavy and light chain and returns models of the antibody fV fragment. Input Heavy...

Force Disulfide

The force disulfide protocol mutates a specified set of residue pairs to cysteines, forms disulfide bonds between them, and then performs a constrained Rosetta relaxation of the entire protein in order to minimize the energy. The score of the resulting model is then...

API

The Cyrus API The Cyrus API is a cloud based system that runs molecular modeling protocols developed by Cyrus Biotechnology.  Each service in the API shares a common interface for submitting and managing jobs as well as retrieving results. A Command Line Application...

Single Chain HM

The disulfide single chain homology modeling API creates homology models of single chain proteins using the Rosetta hybridize homology modeling method.  By default, the hybridize method will automatically identify templates to use to construct the model. However, a...

Disulfidizer

The Disulfidizer API runs the Rosetta “Disulfidizer” protocol. The disfulfidizer protocol attempts to stabilize a protein by making disulfide bonds. This method has been used widely with atomic-resolution success for de novo designed small proteins, and less...

API Services

Disulfide Modeling Cyrus provides you with three options for disulfide modeling: Disulfidizer, Force Disulfide, and Single Chain HM.  They are described in greater detail below; in this section we discuss their relative strengths, weaknesses, and purpose. Force...

Python Library Usage

Jobs can be submitted and results retrieved using a python 3 client library.  Each API service has a separate client object which is constructed with the following arguments: client_id — The client ID obtained from https://api-authorization.cyrusbio.com/ secret...

Command Line Usage

The Cyrus Engine tool is expressed via the cyrus command line application that is used to submit API commands, retrieve the results, and check the status of running jobs. All available Cyrus APIs can be accessed using cyrus. Installation Windows Open the zip file...

Authentication

 All requests to the API are authenticated with a client ID and secret key to protect your data. The client ID and secret key can be obtained by logging into https://api-authorization.cyrusbio.com/ with your Cyrus account. You will need to obtain the client ID and...