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Designing Bispecific Antibodies

Click Here to Download This Article as a PDF INTRODUCTION The overarching goal of this workflow is to show Bench users how they may use their understanding of a complex protein-protein interface to generate specificity variants on that sequence, yielding orthogonal...

Sorting Design Sequence

INTRODUCTION TO PROTEIN DESIGN RESULTS  Our Design tools are often used as a way to find multiple mutations that improve Rosetta Energy. We recommend running 100 repeats of a design. Then look at the range of results to find favorable mutations. Instructions on how to...

Create a PSSM

BACKGROUND A protein Position Specific Scoring Matrix (PSSM) takes the alignment of your protein to a list of homologs and counts the amino acids found at each position for the homologs. This is an easy way of measuring evolutionarily related mutations accepted at...